T0201
Tau-381 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
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About This Item
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
Form
lyophilized powder
Mol-Gew.
39.7 kDa
UniProt-Hinterlegungsnummer
Anwendung(en)
cell analysis
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
human ... MAPT(4137)
Allgemeine Beschreibung
The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.
Biochem./physiol. Wirkung
Microtubule associated protein tau (MAPT) aids in the assembly and maintenance of microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).
Isoform of Tau, variant 1N3R, having 3 microtubule binding repeats (R) and one amino terminal insert (N).
Rekonstituierung
Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
A.J. Myers
Human Molecular Genetics (2005)
Microdeletion encompassing MAPT at chromosome 17q21. 3 is associated with developmental delay and learning disability
Shaw-Smith, Charles, et al
Nature Genetics (2006)
A Himmler et al.
Molecular and cellular biology, 9(4), 1381-1388 (1989-04-01)
Tau proteins consist of a family of proteins, heterogeneous in size, which associate with microtubules in vivo and are induced during neurite outgrowth. In humans, tau is one of the major components of the pathognomonic neurofibrillary tangles in Alzheimer's disease
Jesus Avila et al.
Physiological reviews, 84(2), 361-384 (2004-03-27)
The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated
M Goedert et al.
Neuron, 3(4), 519-526 (1989-10-01)
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with
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