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SRP6392

Sigma-Aldrich

CD47 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(e):

IAP, MER6, OA3

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in HEK 293 cells

Markierung

6-His tagged (C-terminus)

Assay

≥95% (SDS-PAGE)

Form

lyophilized

Mol-Gew.

calculated mol wt 14.5 kDa
observed mol wt 35-43 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 19 is the predicted N-terminus.)

Verpackung

pkg of 10 μg

Verunreinigungen

<1 EU/μg endotoxin (LAL test)

UniProt-Hinterlegungsnummer

Q08722

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... CD47(961)

Allgemeine Beschreibung

Leukocyte surface antigen CD47 also known as antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances super antigen-dependent T-cell-mediated proliferation and co-stimulates T-cell activation.

Physikalische Form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Rekonstituierung

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Gongchu Li et al.
Oncotarget, 6(41), 43496-43507 (2015-11-12)
Our previous studies have suggested that harboring a soluble coxsackie-adenovirus receptor-ligand (sCAR-ligand) fusion protein expression cassette in the viral genome may provide a universal method to redirect oncolytic adenoviruses to various membrane receptors on cancer cells resisting to serotype 5
Fatemeh Faraji et al.
Biotechnology and applied biochemistry, 65(5), 718-725 (2018-03-16)
CD22 is a B-cell-specific trans-membrane glycoprotein, which is found on the surface of the most B cells and modulates their function, survival, and apoptosis. Recently, targeting this cell surface biomarker in B-cell malignancies and disorders has attracted a lot of

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