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Key Documents

SRP5156

Sigma-Aldrich

14-3-3 ζ, untagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

14-3-3 ζ, KCIP-1, MGC111427, MGC126532, MGC138156, YWHAZ

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About This Item

CAS-Nummer:
1173938-18-5
UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Mol-Gew.

~29 kDa

NCBI-Hinterlegungsnummer

NM_003406

Anwendung(en)

cell analysis

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... YWHAZ(7534)

Allgemeine Beschreibung

14-3-3ζ (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3ζ protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis. 14-3-3ζ protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1.

Physikalische Form

Supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Angaben zur Herstellung

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Zenggang Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(1), 162-167 (2007-12-29)
The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and pathological conditions. Here, we report an important role of 14-3-3zeta in tumorigenesis through a mechanism that involves anoikis resistance. 14-3-3zeta is up-regulated
M Niemantsverdriet et al.
Oncogene, 27(9), 1315-1319 (2007-08-21)
14-3-3 proteins are relevant to cancer biology as they are key regulators of major cellular processes such as proliferation, differentiation, senescence and apoptosis. So far, the sigma isoform (14-3-3sigma) has most directly been implicated in carcinogenesis and was recognized as

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