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Wichtige Dokumente

SRP0422

PARP5A active human

Name: PARP5A active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)

Synonym(e):

PARP5a, TNKS1, Tankyrase1, poly(ADP-ribosyl)transferase 5a

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About This Item

UNSPSC-Code:

12352200

NACRES:

NA.32

Biologische Quelle

human

Rekombinant

expressed in baculovirus infected Sf9 cells

Assay

≥30% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

62.5 kDa

Verpackung

pkg of 10 μg

NCBI-Hinterlegungsnummer

NM_003747

UniProt-Hinterlegungsnummer

O95271

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... TNKS(8658)

Allgemeine Beschreibung

TNKS1 (TRF1-interacting ankyrin-related ADP-ribose polymerase 1), also known as PARP5A, TANK1, or tanykyrase-1 (GenBank Accession No. NM_003747), amino acids 1000-1328 (end) with N-terminal GST-tag, MW=62.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

N McCabe et al.

Oncogene, 28(11), 1465-1470 (2009-02-03)

The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutations in either BRCA1 or BRCA2 strongly predispose carriers to cancers of the breast and other organs. It has been demonstrated previously that inhibiting

Tankyrase is necessary for canonical Wnt signaling during kidney development.

Courtney M Karner et al.

Developmental dynamics : an official publication of the American Association of Anatomists, 239(7), 2014-2023 (2010-06-16)

Recent studies using small molecule antagonists have revealed that the poly(ADP-ribose) polymerases (PARPs) Tankyrase 1 and 2 are critical regulators of canonical Wnt signaling in some cellular contexts. However, the absence of any activity during zebrafish embryogenesis suggested that the

The telomere protein tankyrase 1 regulates DNA damage responses at telomeres.

Sandy Chang

Aging, 2(10), 639-642 (2010-11-16)

The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates

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