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Key Documents

SRP0340

Axl active human

Name: Axl active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Synonym(e):

AXL receptor tyrosine kinase, JTK11, UFO

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About This Item

CAS-Nummer:

153190-63-7

UNSPSC-Code:

12352200

NACRES:

NA.32

Biologische Quelle

human

Rekombinant

expressed in baculovirus infected Sf9 cells

Assay

≥70% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

77 kDa

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

activity assay: suitable
inhibition assay: suitable

NCBI-Hinterlegungsnummer

NM_021913

UniProt-Hinterlegungsnummer

P30530

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... AXL(558)

Allgemeine Beschreibung

AXL (GenBank Accession No. NM_021913), amino acids 473-894 with N-terminal GST-tag, MW= 77 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Einheitendefinition

One unit is defined as the amount of enzyme that will transfer 1 nmol phosphate to Tyr substrate per minute at pH 7.4 and 30° C.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway.

Tateo Sawabu et al.

Molecular carcinogenesis, 46(2), 155-164 (2006-12-23)

Activation of tyrosine kinases is an important factor during cancer development. Axl, one of the receptor tyrosine kinases, binds to the specific ligand growth arrest-specific gene 6 (Gas6), which encodes a vitamin K-dependent gamma-carboxyglutamyl protein. Although many receptor tyrosine kinases

Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity.

Gaetano Zizzo et al.

Arthritis research & therapy, 15(6), R212-R212 (2013-12-12)

Systemic lupus erythematosus (SLE) is characterized by impaired efferocytosis and aberrant activation of innate immunity. We asked if shedding of MER receptor tyrosine kinase (MerTK) and AXL into soluble (s) ectodomains was related to immunological and clinical aspects of SLE.

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells.

M Vouri et al.

Oncogenesis, 5(10), e266-e266 (2016-10-25)

Acquired resistance to conventional and targeted therapies is becoming a major hindrance in cancer management. It is increasingly clear that cancer cells are able to evolve and rewire canonical signalling pathways to their advantage, thus evading cell death and promoting

Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.

Peter Vajkoczy et al.

Proceedings of the National Academy of Sciences of the United States of America, 103(15), 5799-5804 (2006-04-06)

Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular events underlying gliomagenesis are poorly understood. In this study, we have identified the receptor tyrosine kinase Axl as a mediator of glioma growth

Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancer.

Xiao-Han Qu et al.

Oncology letters, 10(3), 1677-1685 (2015-12-02)

Lung cancer has long been one of the most serious types of malignant tumor, and is associated with high incidence and mortality rates. Despite advancements in the comprehensive treatment of the disease, particularly with targeted therapeutic agents, there has been

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