SML3922

A-784168

≥98% (HPLC)

• Synonym(e): 1-[3-(Trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-1,2,3,6-tetrahydropyridine-4-carboxamide, 3′-(Trifluoromethyl)-N-{4-[(trifluoromethyl)thio]phenyl}-3,6-dihydro-2H-1,2′-bipyridine-4-carboxamide, A 784168, A784168
• Empirische Formel (Hill-System): C₁₉H₁₅F₆N₃O₃S
• CAS-Nummer: 824982-41-4
• Molekulargewicht: 479.40
• MDL-Nummer: MFCD22373772
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

Brain-penetrant, orally active, potent and selective transient receptor potential cation channel TRPV1 antagonist with in vivo analgesia efficacy.

A-784168 is a brain-penetrant, orally active, potent and selective transient receptor potential (TRP) cation channel TRPV1 antagonist (IC50 = 25/14/33.7/35.1 nM against TRPV1 activation by 50 nM capsaicin/pH 5.5/3 µM NADA/10 µM anandamide in human TRPV1 tranfectants) with little activity or affinity toward other TRP channels and a panel of 74 neurotransmitter receptors. A-784168 reduces capsaicin-induced acute pain (ED50 = 10 µmol/kg p.o. 1h before capsaicin intraplantar injection) and CFA paw injection-induced chronic inflammatory thermal hyperalgesia (EC50 = 54 nmol) in rats in vivo.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable