SML3817

TLR2-IN-C29

≥98% (HPLC)

• Synonym(e): 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methylbenzoic acid, C29
• Empirische Formel (Hill-System): C₁₆H₁₅NO₄
• CAS-Nummer: 363600-92-4
• Molekulargewicht: 285.29
• UNSPSC-Code: 51111800
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow to orange
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C
• SMILES String: O=C(C1=C(C)C(N=CC2=C(O)C(OC)=CC=C2)=CC=C1)O

Beschreibung

Biochem./physiol. Wirkung

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist that inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable