SML3744

Ac-FLTD-CMK

≥95% (HPLC)

• Synonym(e): N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone
• Empirische Formel (Hill-System): C₂₆H₃₇ClN₄O₈
• CAS-Nummer: 2376255-48-8
• Molekulargewicht: 569.05
• MDL-Nummer: MFCD32874101
• UNSPSC-Code: 51111800
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: (Powder or Lyophilized powder or film)
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) that suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.

Vorsicht

Hygroscopic

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable