SML3723

JNJ-26854165

≥98% (HPLC)

• Synonym(e): 1-N-[2-(1H-Indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, JNJ 1, JNJ 26854165, N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, Serdemetan
• Empirische Formel (Hill-System): C₂₁H₂₀N₄
• CAS-Nummer: 881202-45-5
• Molekulargewicht: 328.41
• MDL-Nummer: MFCD16620518
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [nH]1c2c(c(c1)CCNc3ccc(cc3)Nc4ccncc4)cccc2
• InChIKey: CEGSUKYESLWKJP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Inhibitor of the E3 ligase human double minute-2 (HDM2); cholesterol transport inhibitor

JNJ-26854165 (serdemetan) is an inhibitor of the E3 ligase human double minute-2 (HDM2) that inhibits cell proliferation and induces apoptosis in models of acute myeloid and lymphoid leukemias, and solid tumors. Also JNJ-26854165 inhibits cholesterol transport. JNJ-26854165 appears to stimulate cholesterol regulatory genes, but simultaneously inhibits cholesterol transport.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable