SML3279

BC-2059

≥98% (HPLC)

• Synonym(e): BC 2059, BC2059, Tegatrabetan, Tegavivint, rel-2,7-Bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-9,10-anthracenedione 9,10-dioxime
• Empirische Formel (Hill-System): C₂₈H₃₆N₄O₆S₂
• CAS-Nummer: 1227637-23-1
• Molekulargewicht: 588.74
• MDL-Nummer: MFCD32661883
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C

Beschreibung

Biochem./physiol. Wirkung

BC-2059 is a cell penetrant, potent and selective inhibitor of the Wnt-signaling pathway that potently inhibits growth of cancer cell lines in vitro. BC-2059 inhibits β-catenin/transducin β-like 1 (TBL1) complex by direct binding to TBL1 complexed with β-catenin. BC-2059 does not inhibit interaction of TBL1 with either NCoR/SMRT or NFkB. It is a potential therapeutic for tumors with deregulated Wnt signaling pathway.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable