SML3261

JS6

≥98% (HPLC)

• Synonym(e): 2-(2-Fluorobenzamido)-N-[2-(morpholin-4-yl)ethyl]benzamide, 2-Fluoro-N-(2-(2-morpholinoethylcarbamoyl)phenyl)benzamide, 2-[(2-Fluorobenzoyl)amino]-N-[2-(4-morpholinyl)ethyl]benzamide
• Empirische Formel (Hill-System): C₂₀H₂₂FN₃O₃
• CAS-Nummer: 950244-33-4
• Molekulargewicht: 371.41
• UNSPSC-Code: 12352107
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(C1=CC=CC=C1NC(C2=C(C=CC=C2)F)=O)NCCN3CCOCC3
• InChIKey: QEEPXSHOUBCRGQ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Bcl3:NF-kB p50 protein-protein interaction (PPI) inhibitor with anti-metastatic efficacy in cultures and in vivo.

JS6 is a Bcl3:NF-kB p50 protein-protein interaction (PPI) inhibitor that effectively suppresses Bcl3-dependent intracellular NF-kB activity (IC50 = 45/159 nM using Bcl3-overexpressing MDA-MB-231/HEK293; IC50 = 710 nM using HEK293 overexpressing Bcl3 and NF-kB p52). JS6 prevents enhanced MDA-MB-231 migration upon Bcl3 overexpression in cultures (IC50 = 310 nM), and effectively suppresses primary tumor growth as well as secondary tumor colonisation in vivo (3.5-10 mg/kg/d i.p. mice with MDA-MB-436 or 4T1.2 murine carcinoma xenograft) without overt systemic toxicity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable