SML3082

Demethylwedelolactone

≥98% (HPLC)

• Synonym(e): 1,3,8,9-Tetrahydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 1,3,8,9-Tetrahydroxy-6H-benzofuro[3,2-c]chromen-6-one; 1,3,8,9-Tetrahydroxycoumestan, Desmethylwedelolactone, Norwedelolactone
• Empirische Formel (Hill-System): C₁₅H₈O₇
• CAS-Nummer: 6468-55-9
• Molekulargewicht: 300.22
• MDL-Nummer: MFCD09264645
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to green
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=C1OC2=C(C(O)=CC(O)=C2)C3=C1C4=C(O3)C=C(O)C(O)=C4
• InChI: 1S/C15H8O7/c16-5-1-9(19)13-11(2-5)22-15(20)12-6-3-7(17)8(18)4-10(6)21-14(12)13/h1-4,16-19H
• InChIKey: LUTYTNLPIUCKBJ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Demethylwedelolactone is a coumestan extracted from Eclipta alba that exhibits numerous biological activities including anti-inflammatory and hepato-protective. Demethylwedelolactone inhibits MDA-MB-231 breast cancer cells motility and invasiveness. It suppresses the metastasis and lung colonization of the tumor cells in the nude mice. Both demethylwedelolactone and wedelolactone appear to attenuate cigarette smoking extract induced inflammation through blockade of autophagy flux in respiratory epithelial cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable