SML2622

ABC1183

≥98% (HPLC)

• Synonym(e): 4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile, 4-[[4-Amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]-benzonitrile
• Empirische Formel (Hill-System): C₁₈H₁₄N₄OS
• CAS-Nummer: 1042735-18-1
• Molekulargewicht: 334.39
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: NC1=C(C(C2=CC=C(C=C2)C#N)=O)SC(NC3=CC=C(C)C=C3)=N1
• InChI: 1S/C18H14N4OS/c1-11-2-8-14(9-3-11)21-18-22-17(20)16(24-18)15(23)13-6-4-12(10-19)5-7-13/h2-9H,20H2,1H3,(H,21,22)
• InChIKey: CUDLEXBIVZPJBU-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ABC1183 is an orally active, potent and selective inhibitor of GSK3 α/β and CDK9, which induces G2/M cell cycle arrest and apoptosis in cancer cells. Apparently ABC1183 suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms due to down regulation of TNFα and IL-6 pro-inflammatory cytokines. It does not exhibit organ or hematological toxicities.

an orally active, potent and selective inhibitor of GSK3 α/β and CDK9

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable