SML2348

BAY-707

≥98% (HPLC)

• Synonym(e): (S)-N-Ethyl-4-(3-methylmorpholino)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
• Empirische Formel (Hill-System): C₁₅H₂₀N₄O₂
• CAS-Nummer: 2109805-96-9
• Molekulargewicht: 288.34
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(NCC)C1=CC2=C(N1)N=CC=C2N3CCOC[C@@H]3C
• InChI: 1S/C15H20N4O2/c1-3-16-15(20)12-8-11-13(4-5-17-14(11)18-12)19-6-7-21-9-10(19)2/h4-5,8,10H,3,6-7,9H2,1-2H3,(H,16,20)(H,17,18)/t10-/m0/s1
• InChIKey: RPMGXDCRCWWCRY-JTQLQIEISA-N

Beschreibung

Biochem./physiol. Wirkung

BAY-707 is an inhibitor of the human 7,8-dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1), which hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage. BAY-707 was shown to be a substrate-competitive, selective MTH1 inhibitor with an IC50 value of 2.3 nM.

Inhibitor of the human 7,8-dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable