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SML2090

Sigma-Aldrich

NAMI-A

≥98% ruthenium (Ru) basis (elemental analysis)

Synonym(e):

1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-κN3)[1,1′-(sulfinyl-κS)bis[methane]]ruthenate(1-) (1:1), ImH[trans-RuCl4(DMSO)Im], Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate

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About This Item

Empirische Formel (Hill-System):
C5H10Cl4N2ORuS · C3H5N2
CAS-Nummer:
201653-76-1
Molekulargewicht:
458.18
UNSPSC-Code:
12352200
NACRES:
NA.77

Assay

≥98% ruthenium (Ru) basis (elemental analysis)

Form

powder

Lagerbedingungen

desiccated

Farbe

faint red to dark brown

Löslichkeit

H2O: 2 mg/mL, clear

Lagertemp.

−20°C

SMILES String

CS(C)=O.Cl[Ru](Cl)(Cl)Cl.N1=CNC=C1.C2=[NH+]C=CN2

Biochem./physiol. Wirkung

NAMI-A is a potent antimetastatic drug in vivo that is exhibits little cytotoxicity towards many cancer cell lines. Antimetastatic of NAMI-A is attributed to the formation of adducts with membrane and cytosolic proteins. Nevertheless NAMI-A induces potent and selective cytotoxic effects in several leukemia cell lines. NAMI-A exhibits low toxicity for host tissues.
NAMI-A is a ruthenium-based anticancer agent.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Alberta Bergamo et al.
Journal of inorganic biochemistry, 168, 90-97 (2017-01-09)
Solid tumours are constituted of tumour cells, healthy cells recruited from the host tissues and soluble factors released by both these cell types. The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116
K Śpiewak et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 695-703 (2015-03-21)
Imidazolium trans-tetrachloridodimethylsulfoxideimidazolruthenate(III), NAMI-A, a novel antimetastatic ruthenium complex was investigated towards affinity to transferrin (Tf), whether Tf-Ru adducts might be formed after its intravenous injection. Studies were focused on the holotransferrin due to its preferential binding to transferrin receptor. Here
Serena Pillozzi et al.
Dalton transactions (Cambridge, England : 2003), 43(32), 12150-12155 (2014-07-01)
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic"

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