SML1452

Ibufenac

≥95% (HPLC)

• Synonym(e): 4-(2-Methylpropyl)-benzeneacetic acid, 4-Isobutylphenylacetic acid
• Empirische Formel (Hill-System): C₁₂H₁₆O₂
• CAS-Nummer: 1553-60-2
• Molekulargewicht: 192.25
• EG-Nummer: 216-302-2
• MDL-Nummer: MFCD00864374
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825891
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: OC(CC1=CC=C(CC(C)C)C=C1)=O
• InChI: 1S/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)
• InChIKey: CYWFCPPBTWOZSF-UHFFFAOYSA-N
• Angaben zum Gen: human ... PTGS1(5742) , PTGS2(5743)

Beschreibung

Biochem./physiol. Wirkung

Ibufenac is a non-steroidal anti-inflammatory drug (NSAID) analog of ibuprofen that was withdrawn for hepatotoxicity. It inhibits cyclooxygenases COX-1 and -2 activity with IC50 values of 17.4 and 13.1 μM, respectively and > 40 μM for 5-LOX. It has been used in studies of drug-induced hepatotoxicity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable