SML1353

ML351

≥98% (HPLC)

• Synonym(e): 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile, CID 664510, ML 351, SID 104223766
• Empirische Formel (Hill-System): C₁₅H₁₁N₃O
• CAS-Nummer: 847163-28-4
• Molekulargewicht: 249.27
• MDL-Nummer: MFCD04183120
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825808
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2
• InChI: 1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3
• InChIKey: DYXYXTDIFMDJIR-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable