SML1075

Atglistatin

≥98% (HPLC), powder, adipose triglyceride lipase inhibitor

• Synonym(e): 3-(4′-(Dimethylamino)-[1,1′-biphenyl]-3-yl)-1,1-dimethylurea
• Empirische Formel (Hill-System): C₁₇H₂₁N₃O
• CAS-Nummer: 1469924-27-3
• Molekulargewicht: 283.37
• MDL-Nummer: MFCD28009494
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825457
• NACRES: NA.77

Eigenschaften

• product name: Atglistatin, ≥98% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O
• InChI: 1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
• InChIKey: AWOPBSAJHCUSAS-UHFFFAOYSA-N

Beschreibung

Anwendung

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

Biochem./physiol. Wirkung

Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC₅₀ of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

Sonstige Hinweise

Produced under the license of University of Graz/Graz University of Technolog

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable