SML0884

bpV(HOpic)

≥90% V basis

• Synonym(e): Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K₂[VO(O₂)2C₆H₄NO₃]
• Empirische Formel (Hill-System): K₂VOO₂O₂C₆H₄NO₃
• CAS-Nummer: 722494-26-0
• Molekulargewicht: 347.24
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥90% V basis
• Form: powder
• Lagerbedingungen: desiccated; protect from light
• Farbe: faintly yellow to dark yellow
• Löslichkeit: H₂O: 20 mg/mL, clear
• Lagertemp.: −20°C

Beschreibung

Anwendung

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.

Biochem./physiol. Wirkung

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.

Sonstige Hinweise

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable