SML0760

WIKI4

≥98% (HPLC)

• Synonym(e): 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1Hbenz[de]isoquinoline-1,3(2H)-dione
• Empirische Formel (Hill-System): C₂₉H₂₃N₅O₃S
• CAS-Nummer: 838818-26-1
• Molekulargewicht: 521.59
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear (warmed)
• Lagertemp.: −20°C
• InChI: 1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3
• InChIKey: RNUXIZKXJOGYQP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling with an EC₅₀ ~ 75 nM in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U2OS osteosarcoma cells, and hESCs. WIKI4 inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) with an IC₅₀ of 15 nM, preventing the ubiquitination and degradation of axin and thereby antagonizing Wnt signalling.

Leistungsmerkmale und Vorteile

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.