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SML0742

Sigma-Aldrich

EUK-8

≥95% (HPLC)

Synonym(e):

(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese, (Salen)manganese(III) chloride, Chloro(bis(salicylidene)ethylenediamine)manganese, Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese, EUK 8, Manganese(salen) chloride

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About This Item

Empirische Formel (Hill-System):
C16H14ClMnN2O2
CAS-Nummer:
53177-12-1
Molekulargewicht:
356.69
UNSPSC-Code:
12352200
NACRES:
NA.77

Assay

≥95% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

, faint to very dark brown

Löslichkeit

H2O: 1 mg/mL, clear

Lagertemp.

−20°C

InChI

1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3

InChIKey

HBQGFROGWOHBAG-UHFFFAOYSA-K

Biochem./physiol. Wirkung

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

Sonstige Hinweise

air sensitive

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Stefanie J Ophoven et al.
Anticancer research, 30(10), 3967-3979 (2010-11-03)
Salen-manganese complexes, such as EUK-8 and EUK-134 are known as catalase mimetics with superoxide dismutase (SOD) and peroxidase mimetic activity. Here we show that the concentration-dependent use of salen-manganese complexes within the appropriate time window and with parallel control of
Toru Sasaki et al.
Aging cell, 7(4), 459-469 (2008-04-19)
Oxidative stress, an imbalance between endogenous levels of oxygen radicals and antioxidative defense, increases with aging. However, it is not clear which of these two factors is the more critical. To clarify the production of oxygen radicals increases with age
Can Li et al.
Chemical communications (Cambridge, England), (6)(6), 547-558 (2007-02-01)
This article reviews the recent progress made in asymmetric catalysis in the nanopores of mesoporous materials and periodic mesoporous organosilicas (PMOs). Some examples of chiral catalysts within the nanopores show improved catalytic performance compared to homogeneous catalysts. The factors including
M Ata Secilmis et al.
Acta pharmacologica Sinica, 29(6), 687-697 (2008-05-27)
The aim of this study was to investigate whether superoxide dismutase (SOD) enzymes and ascorbate play a role in the protection of the nitrergic relaxation against superoxide anion inhibition in the mouse duodenum. The effects of exogenous SOD, N,No-bis(salicylidene) ethylenediamine
Samanta Do Amaral et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 21(4), 425-432 (2007-12-29)
The catalase mimetic complex Mn(III)-salen chloride (EUK8) was found to be pro-oxidant under low hydrogen peroxide concentrations. The increase in the fluorescence rate of the probe 1,2,3-dihydrorhodamine (DHR) in solution, as well as the carbonyl content of human serum albumin
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