SML0501

SB-590885

≥98% (HPLC)

• Synonym(e): 5-(2-(4-(2-Dimethylaminoethoxy)phenyl)-5-(4-pyridinyl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
• Empirische Formel (Hill-System): C₂₇H₂₇N₅O₂
• CAS-Nummer: 405554-55-4
• Molekulargewicht: 453.54
• MDL-Nummer: MFCD16038645
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825450
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL (clear solution, warmed)
• Lagertemp.: 2-8°C
• SMILES String: CN(C)CCOc1ccc(cc1)-c2nc(-c3ccc4c(CC\C4=N\O)c3)c([nH]2)-c5ccncc5
• InChI: 1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24-
• InChIKey: MLSAQOINCGAULQ-QLTSDVKISA-N

Beschreibung

Anwendung

SB-590885 has been used as a component of a mixture to maintain naive human pluripotent stem cells (PSCs).It has also been used as B-Raf (BRAF) inhibitor to study its effects on lung adenocarcinoma cell lines.

Biochem./physiol. Wirkung

SB-590885 is a potent and selective ATP competitive inhibitor of B-Raf kinase with Kd = 300 pM for B-Raf, and >1000-fold selectivity over a panel of 22 commonly studied cellular kinases

SB-590885 is a potent and selective B-Raf kinase inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable