SML0496

CORM-3

• Synonym(e): Carbon monoxide releasing molecule 3, Tricarbonylchloro(glycinato)ruthenium (II)
• Empirische Formel (Hill-System): C₅H₄ClNO₅Ru
• CAS-Nummer: 475473-26-8
• Molekulargewicht: 294.61
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 20 mg/mL, clear
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: [Ru+2].[Cl-].NCC(=O)[O-].O=[C].O=[C].O=[C]
• InChI: 1S/C2H5NO2.3CO.ClH.Ru/c3-1-2(4)5;3*1-2;;/h1,3H2,(H,4,5);;;;1H;/q;;;;;+2/p-2

Beschreibung

Anwendung

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H₂O₂-induced apoptosis using primary rabbit lens epithelial cells.

Biochem./physiol. Wirkung

CO possesses anti apoptotic function and offers protection against oxidative damage, promoting endothelial healing. CORM-3 is known to have therapeutic effects in transplantation, myocardial infarction and rheumatoid arthritis.

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable