SML0475

CGP36742

≥97% (NMR)

• Synonym(e): P-(3-Aminopropyl)-P-butyl-phosphinic acid, SGS 742
• Empirische Formel (Hill-System): C₇H₁₈NO₂P
• CAS-Nummer: 123690-78-8
• Molekulargewicht: 179.20
• MDL-Nummer: MFCD00882735
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825430
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (NMR)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 10 mg/mL (clear solution, warmed)
• Lagertemp.: room temp
• SMILES String: CCCCP(O)(=O)CCCN
• InChI: 1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
• InChIKey: ONNMDRQRSGKZCN-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

CGP36742 was the first orally active GABAB-selective antagonist. The IC₅₀ for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H319
• P-Sätze: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable