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SML0224

Sigma-Aldrich

HI-6

≥98% (HPLC)

Synonym(e):

1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride, 4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride, Asoxime chloride, HI 6, HI 6 chloride, HJ 6, Transant

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About This Item

Empirische Formel (Hill-System):
C14H16N4O3 · 2Cl
CAS-Nummer:
34433-31-3
Molekulargewicht:
359.21
MDL-Nummer:
MFCD00869535
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825243
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

H2O: 15 mg/mL (clear solution)

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1

InChI

1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H

InChIKey

QELSIJXWEROXOE-UHFFFAOYSA-N

Allgemeine Beschreibung

HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.

Biochem./physiol. Wirkung

HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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T Seeger et al.
Toxicology letters, 206(1), 72-76 (2011-08-02)
An important factor for successful therapy of poisoning with organophosphorus compounds (OP) is the rapid restoration of blocked respiratory muscle function. To achieve this goal, oximes are administered for reactivation of inhibited acetylcholinesterase (AChE). Unfortunately, clinically used oximes, e.g. obidoxime
James P Apland et al.
The Journal of pharmacology and experimental therapeutics, 344(1), 133-140 (2012-10-09)
Control of brain seizures after exposure to nerve agents is imperative for the prevention of brain damage and death. Animal models of nerve agent exposure make use of pretreatments, or medication administered within 1 minute after exposure, in order to
Jana Zdarova Karasova et al.
Toxicology letters, 220(2), 167-171 (2013-04-30)
Pigs were administered intramuscularly molar equivalents of HI-6 salts (HI-6 dichloride 10.71 mg/kg and HI-6 DMS 13.59 mg/kg) either with or without hyaluronidase (60 U/kg). Hyaluronidase is supposed to increase tissue permeability and diminishes discomfort caused by the intramuscular injection.
Miroslav Pohanka et al.
Environmental toxicology and pharmacology, 32(1), 75-81 (2011-07-27)
Asoxime (HI-6) is a well known oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited even by sarin or soman. The present experiment was aimed to determine markers of oxidative stress represented
Helen Mumford et al.
Chemico-biological interactions, 203(1), 160-166 (2012-09-18)
Potent organophosphorous (OP) agents, such as VX, are hazardous by absorption through the skin and are resistant to conventional pharmacological antidotal treatments. The residence time of a stoichiometric bioscavenger, human butyrylcholinesterase (huBuChE), in the plasma more closely matches that of
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