SCP0224
Prostate Specific Antigen Substrate
≥95% (HPLC), lyophilized
Synonym(e):
KLK3, Kallikrein-related peptidase-3, PSA
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C44H64N12O13
Molekulargewicht:
969.05
UNSPSC-Code:
12352204
NACRES:
NA.32
Empfohlene Produkte
product name
Prostate Specific Antigen Substrate,
Assay
≥95% (HPLC)
Form
lyophilized
Zusammensetzung
Peptide Content, ≥75%
Lagerbedingungen
protect from light
Lagertemp.
−20°C
Amino Acid Sequence
Mu-His-Ser-Ser-Lys-Leu-Gln-AMC
Allgemeine Beschreibung
Prostate specific antigen (PSA) is a kallikrein-related serine peptidase that belongs to the chymotrypsin subfamily serine protease. It was originally found in human semen. PSA is also detected in serum correlated to benign and metastatic disease.
Anwendung
Prostate Specific Antigen Substrate has been used to assay recombinant severe acute respiratory syndrome coronavirus-2 viral 3-chymotrypsin-like cysteine protease (SARS-CoV-2 3CLpro).
Biochem./physiol. Wirkung
Prostate specific antigen (PSA). It exhibits chymotrypsin-like activity. PSA is the most abundant protease found in the prostate and secreted into the seminal fluid. It is a useful biomarker for prostate cancer. PSA digests the gel-forming proteins semenogelins I and II in semen. It shows antiangiogenic activity in vitro and in vivo.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Anneliese S Ashhurst et al.
Journal of medicinal chemistry, 65(4), 2956-2970 (2021-11-04)
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as potent inhibitors
Drake M Mellott et al.
ACS chemical biology, 16(4), 642-650 (2021-04-01)
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SARS-CoV-2 viral infectivity in several
Anneliese S Ashhurst et al.
bioRxiv : the preprint server for biology (2021-01-06)
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a
Johanna M Mattsson et al.
PloS one, 9(9), e107819-e107819 (2014-09-23)
Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is the liquefaction of the clot formed after ejaculation by cleavage of semenogelins I and II in seminal fluid. PSA also cleaves several
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