SAB5700817

Anti-p53 antibody produced in rabbit

• Synonym(e): BCC7, LFS1, P53, TP53, TRP53, Tp53, Trp53, bbl, bfy, bhy, p44, p53
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 43
• Speziesreaktivität: human, rat, mouse
• Konzentration: 1.14 mg/ml
• Methode(n): ChIP: 1:20-1:50; immunohistochemistry: 1:50-1:200; immunoprecipitation (IP): 1:20-1:50; western blot: 1:3000-1:6000
• UniProt-Hinterlegungsnummer: P02340
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TP53(7157) ; mouse ... Trp53(22059)

Beschreibung

Allgemeine Beschreibung

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p53 (NP_000537.3).

Physikalische Form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Lagerung und Haltbarkeit

Store at -20℃. Avoid freeze / thaw cycles.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable