SAB5700635

Anti-Cyclin D1 antibody produced in rabbit

• Synonym(e): BCL1, CCND1, Cyclin D1, D11S287E, PRAD1, U21B31, cyclin D1
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 33
• Speziesreaktivität: rat, human
• Konzentration: 0.74 mg/ml
• Methode(n): immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• UniProt-Hinterlegungsnummer: P24385
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CCND1(595)

Beschreibung

Allgemeine Beschreibung

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 96-295 of human Cyclin D1 (NP_444284.1).

Physikalische Form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Lagerung und Haltbarkeit

Store at -20℃. Avoid freeze / thaw cycles.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable