SAB5700472

Anti-Phospho-PLCG2-Y1217 antibody produced in rabbit

• Synonym(e): APLAID, FCAS3, PLC-IV, PLC-gamma-2, PLCG2
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 147
• Speziesreaktivität: mouse, human
• Konzentration: 0.37 mg/ml
• Methode(n): immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProt-Hinterlegungsnummer: P16885
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr1217)
• Angaben zum Gen: human ... PLCG2(5336)

Beschreibung

Allgemeine Beschreibung

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Immunogen

A synthetic phosphorylated peptide around Y1217 of human PLCG2 (NP_002652.2).

Physikalische Form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Lagerung und Haltbarkeit

Store at -20℃. Avoid freeze / thaw cycles.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable