SAB4702067

Monoclonal Anti-CD138 APC produced in mouse

• Synonym(e): SDC, SYND1, syndecan 1
• UNSPSC-Code: 12352203

Eigenschaften

• Konjugat: Allophycocyanin conjugate
• Qualitätsniveau: 100
• Antikörper-Produkttyp: primary antibodies
• Klon: MI15, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: ( Human), ( Non-human primates), rat
• Methode(n): flow cytometry: suitable
• Isotyp: IgG1κ
• UniProt-Hinterlegungsnummer: P18827
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SDC1(6382)

Beschreibung

Allgemeine Beschreibung

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

Spezifität

The mouse monoclonal antibody MI15 recognizes an extracellular epitope of CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.

Immunogen

A mixture of U266 and XG-1 human myeloma cell lines

Physikalische Form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Angaben zur Herstellung

Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Lagerung und Haltbarkeit

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Sonstige Hinweise

The antibody solution should be gently mixed before use.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable