SAB4702008

Monoclonal Anti-CD73 FITC produced in mouse

• Synonym(e): CALJA, E5NT, NT5E, NTE, ecto-5´nucleotidase
• UNSPSC-Code: 12352203

Eigenschaften

• Konjugat: FITC conjugate
• Qualitätsniveau: 100
• Antikörper-Produkttyp: primary antibodies
• Klon: AD2, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: ( Non-human primates), human
• Methode(n): flow cytometry: suitable
• Isotyp: IgG1κ
• UniProt-Hinterlegungsnummer: P21589
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NT5E(4907)

Beschreibung

Allgemeine Beschreibung

CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.

Spezifität

The mouse monoclonal antibody AD2 recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on the surface of T and B cell subsets, follicular dendritic cells and endothelial cells.

Immunogen

pre-B leukemia cells

Physikalische Form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Angaben zur Herstellung

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Lagerung und Haltbarkeit

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Sonstige Hinweise

The antibody solution should be gently mixed before use.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable