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Merck

SAB4503385

Sigma-Aldrich

Anti-USP30 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Deubiquitinating enzyme 30, USP30, Ubiquitin carboxyl-terminal hydrolase 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 58 kDa

Speziesreaktivität

human, rat, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... USP30(84749)

Allgemeine Beschreibung

Anti-USP30 Antibody detects endogenous levels of total USP30 protein.
USP30 (ubiquitin specific peptidase 30) is ubiquitin-specific deubiquitylase. It is located in the mitochondria. It is mapped to human chromosome 12q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human USP30.

Immunogen Range: 31-80

Anwendung

Anti-USP30, N-Terminal antibody has been used in western blotting.

Biochem./physiol. Wirkung

USP30 controls atypical ubiquitin chains on mitochondria and PARK2 (parkinson juvenile disease protein 2) mediated mitophagy.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle
Tamura Y, et al.
The Journal of Physiology, 593(12), 2707-2720 (2015)
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
Cunningham CN, et al.
Nature Cell Biology, 17(2), 160-160 (2015)
Deubiquitinating enzymes regulate PARK2-mediated mitophagy
Wang Y, et al.
Autophagy, 11(4), 595-606 (2015)
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease
Rovelet-Lecrux A, et al.
European Journal of Human Genetics, 20(6), 613-617 (2012)
Ding Yan et al.
Cell death discovery, 7(1), 211-211 (2021-08-13)
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously reported that auranofin, a gold(I)-containing agent

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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