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Merck

SAB4501465

Sigma-Aldrich

Anti-HSP10 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

CHAPERONIN 10 HOMOLOG, GroES HOMOLOG, HEAT-SHOCK 10-KD PROTEIN

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 10 kDa

Speziesreaktivität

rat, mouse, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... HSPE1(3336)

Allgemeine Beschreibung

Anti-HSP10 Antibody detects endogenous levels of total HSP10 protein.
HSP10 (heat shock protein family E member 1) is a molecular chaperone protein, located in mitochondria. It is encoded by HSPE1 (heat shock protein family E member 1) gene, that is located on human chromosome 2q33.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human HSP10.

Immunogen Range: 51-100

Anwendung

Anti-HSP10 antibody has been used in microarray and western blotting.

Biochem./physiol. Wirkung

Overexpression of HSP10 (heat shock protein family E member 1) protein blocks apoptosis and results in poor prognosis of astrocytoma. It participates in immunomodulation and tumor progression.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.
Corrao S, et al.
Open Biology, 4(10) (2014)
Juha J Hulmi et al.
Free radical biology & medicine, 99, 308-322 (2016-10-23)
Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many diseases including Duchenne muscular dystrophy (DMD). Oxidative stress, heat shock proteins, endoplasmic reticulum (ER) stress and its response, i.e.
Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress.
Hulmi JJ, et al.
Free Radical Biology & Medicine, 99, 308-322 (2016)
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins.
Karvinen S, et al.
Experimental Gerontology, 79, 46-54 (2016)
Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
Fan W, et al.
PLoS ONE, 12(10) (2017)

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