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SAB4500896

Sigma-Aldrich

Anti-COPZ1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

ζ1-COP, CGI-120, COPZ, coatomer protein complex, subunit ζ 1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 20 kDa

Speziesreaktivität

human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

P61923

UniProt-Hinterlegungsnummer

P61923

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... COPZ1(22818)

Verwandte Kategorien

Allgemeine Beschreibung

Anti-COPZ1 Antibody detects endogenous levels of total COPZ1 protein.

COPZ1 (coatomer protein complex ζ1) codes for a subunit of coatomer protein complex 1 (COPI). It is a secretory vesicle coat protein. It is located on human chromosome 12q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human COPZ1.

Immunogen Range: 11-60

Anwendung

Anti-COPZ1, N-Terminal antibody has been used in immunohistochemistry , immunofluorescence and western blotting.

Biochem./physiol. Wirkung

COPZ1 (coatomer protein complex ζ1) participates in intracellular traffic and autophagy, and endosome maturation. Suppression of COPZ1 promotes apoptosis in proliferating and nondividing tumor cells.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Maria Chiara Anania et al.
Cancer letters, 410, 201-211 (2017-09-28)
Thyroid carcinoma is generally associated with good prognosis, but no effective treatments are currently available for aggressive forms not cured by standard therapy. To find novel therapeutic targets for this tumor type, we had previously performed a siRNA-based functional screening
Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway
Narkis G, et al.
American Journal of Human Genetics, 81, 589-595 (2007)
Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1
Shtutman M, et al.
Proceedings of the National Academy of Sciences of the USA, 108, 12449-12454 (2011)
Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
Anania MC, et al.
Cancer Letters, 410, 201-211 (2017)
Eileen Sun et al.
Journal of virology, 87(5), 2673-2685 (2012-12-21)
As an obligate pathogen, influenza virus requires host cell factors and compartments to mediate productive infection and to produce infectious progeny virus. Recently, several small interfering RNA (siRNA) knockdown screens revealed influenza virus host dependency proteins, all of which identified

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