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Merck

SAB4300468

Sigma-Aldrich

Anti-PTK2B (Ab-402) antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Anti-CADTK antibody produced in rabbit, Anti-CAKB antibody produced in rabbit, Anti-FADK2 antibody produced in rabbit, Anti-FAK2 antibody produced in rabbit, Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41
Klon:
polyclonal
application:
IF
IHC (p)
WB
Speziesreaktivität:
rat, mouse, human
Methode(n):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
citations:
6

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

~116 kDa

Speziesreaktivität

rat, mouse, human

Konzentration

1 mg/mL

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotyp

IgG

Immunogene Sequenz

(D-I-Y-A-E)

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PTK2B(2185)

Allgemeine Beschreibung

PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1.

Immunogen

Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B.

Anwendung

Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence.

Biochem./physiol. Wirkung

Protein tyrosine kinase 2β(PTK2B) participates in the pathogenesis of Alzheimer′s disease (AD). It induces tumor progression in multiple myeloma. It helps in the multiplication, movement and survival of cells.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Zielbeschreibung

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

A Dual Role for the Nonreceptor Tyrosine Kinase Pyk2 during the Intracellular Trafficking of Human Papillomavirus 16
Gottschalk EY and Meneses PI
Journal of Virology, 89(17), 9103-9114 (2015)
Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses
Li YQ, et al.
Neuroscience Letters, 621, 83-87 (2016)
Whole-genome association studies of alcoholism with loci linked to schizophrenia susceptibility
Namkung J, et al.
BMC Genetics, 6 (2005)
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
Dourlen P, et al.
Molecular Psychiatry, 22(6), 874-883 (2017)
P Dourlen et al.
Molecular psychiatry, 22(6), 874-883 (2016-04-27)
A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate risk genes within these loci

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