SAB4300342

Anti-BAD (Ab-136) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-BBC2 antibody produced in rabbit, Anti-BCL2-associated agonist of cell death antibody produced in rabbit, Anti-BCL2L8 antibody produced in rabbit
• MDL-Nummer: MFCD02097156
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~23 kDa
• Speziesreaktivität: rat, human, mouse
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• Isotyp: IgG
• Immunogene Sequenz: (S-R-S-A-P)
• NCBI-Hinterlegungsnummer: NP_004313.1
• UniProt-Hinterlegungsnummer: Q92934
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BAD(572)

Beschreibung

Allgemeine Beschreibung

BAD (BCL2 associated agonist of cell death) is a proapoptotic protein. It is a 184 kDa protein made of 168 amino acids. It belongs to the Bcl2 family of proteins. The gene encoding it is localized on human chromosome 11q13.

Immunogen

Peptide sequence around aa. 134-138 (S-R-S-A-P), according to the protein BAD.

Biochem./physiol. Wirkung

Phosphorylated BAD (BCL2 associated agonist of cell death) has the ability to interact with 14-3-3 scaffold proteins in the cytoplasm. Dephosphorylated BAD is active and it moves to the outer membrane of mitochondria and make heterodimers with BCL-XL to prevent BCL-XL antiapoptotic activities.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable