SAB4300273

Anti-phospho-ABL1/ABL2 (pTyr^393/429) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-ABL antibody produced in rabbit, Anti-ABLL antibody produced in rabbit, Anti-ARG antibody produced in rabbit, Anti-JTK7 antibody produced in rabbit, Anti-c-abl oncogene 1 / v-abl murine leukemia viral oncogene homolog 2 antibody produced in rabbit
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~210 kDa
• Speziesreaktivität: human, mouse
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotyp: IgG
• Immunogene Sequenz: (D-T-YP-T-A)
• NCBI-Hinterlegungsnummer: NP_001129472.1; NP_005148.2
• UniProt-Hinterlegungsnummer: P42684
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr393/pSer429)
• Angaben zum Gen: human ... ABL1(25) , ABL2(27)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y(p)-T-A), according to the protein ABL1/ABL2.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable