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Merck

SAB4300034

Sigma-Aldrich

Anti-phospho-STAT3 (pSer727) antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Anti-APRF antibody produced in rabbit, Anti-FLJ20882 antibody produced in rabbit, Anti-HIES antibody produced in rabbit, Anti-MGC16063 antibody produced in rabbit, Anti-signal transducer and activator of transcription 3 (acute-phase response factor) antibody produced in rabbit

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

~88 kDa

Speziesreaktivität

mouse, human, rat

Konzentration

1 mg/mL

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotyp

IgG

Immunogene Sequenz

(P-M-SP-P-R)

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pSer727)

Angaben zum Gen

human ... STAT3(6774)

Allgemeine Beschreibung

Signal transducer and activator of transcription 3 (STAT3), a constituent of the interleukin-6- (IL-6) activated acute phase response factor (APRF) complex, belongs to the signal transducer and activator of transcription (STAT) family. It is expressed in all types of tissues. The STAT3 gene with 24 exons is mapped to human chromosome 17q21.2.

Immunogen

Peptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-R), according to the protein STAT3.

Anwendung

Anti-phospho-STAT3 (pSer727) antibody produced in rabbit has been used in immunoblotting (1:1000) and immunofluorescence staining (1:200).

Biochem./physiol. Wirkung

Signal transducer and activator of transcription 3 (STAT3) protein play a key role in cell growth, apoptosis, metabolism, cellular respiration, and autophagy. It may act as a co-activator of signal transduction by glucocorticoid receptors. STAT3 regulates transcription. It is involved in the development of vertebrates and the regulation of inflammation and immunity. It might participate in airway inflammation, allergy, and asthma. Mutations in the STAT3 gene are associated with immunodeficiency, autoimmunity, and cancer.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Zielbeschreibung

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Emily J Hillmer et al.
Cytokine & growth factor reviews, 31, 1-15 (2016-05-18)
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Although the anti-neoplastic effects of physcion are well documented, its specific action in hepatocellular carcinoma (HCC) is not understood. Taken together, physcion is a promising drug candidate for the treatment and prevention of HCC. Cell Counting Kit-8 (CCK-8) assay utilized
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Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes. A bioinformatic analysis indicated a

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