SAB3501155

Monoclonal Anti-DC-SIGN [8B6] antibody produced in mouse

affinity purified immunoglobulin (IgG)

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity purified immunoglobulin (IgG)
• Antikörper-Produkttyp: primary antibodies
• Klon: monoclonal
• Form: liquid
• Speziesreaktivität: human
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG1, kappa
• UniProt-Hinterlegungsnummer: Q9NNX6
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CD209(30835)

Beschreibung

Allgemeine Beschreibung

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Immunogen

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Anwendung

DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Physikalische Form

Supplied in PBS containing 0.02% sodium azide.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable