SAB3500654

Anti-SIGLEC15 antibody produced in rabbit

affinity isolated antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Mol-Gew.: 36 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: 1 mg/mL
• Methode(n): ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_998767
• UniProt-Hinterlegungsnummer: Q6ZMC9
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SIGLEC15(284266)

Beschreibung

Allgemeine Beschreibung

Sialic acid binding Ig like lectin 15 (SIGLEC15) is part of the Siglec family of glycan-recognition proteins. It is expressed in a subset of macrophages. This type-I transmembrane protein possesses two immunoglobulin-like domains, a transmembrane domain and a short cytoplasmic tail. The SIGLEC15 gene is localized on human chromosome 18q12.3.

Immunogen

Antibody was raised against a 15 amino acid peptide near the amino terminus of human SIGLEC15.

Biochem./physiol. Wirkung

Sialic acid binding Ig like lectin 15 (SIGLEC15) recognizes a tumor-linked glycan structure called the sialyl-Tn (sTn) antigen. It is expressed on tumor-associated macrophages in tumor tissues. The protein acts as a signal transducer. SIGLEC15 associates with the adaptor protein DNAX activation protein of 12kDa (DAP12) and transduces a signal to spleen tyrosine kinase (Syk).

Leistungsmerkmale und Vorteile

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Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500654.

Physikalische Form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable