SAB3500417

Anti-RUNX1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-AML1, Anti-AMLCR1, Anti-CBFA2, Anti-EVI-1, Anti-Runt-related transcription factor 1
• MDL-Nummer: MFCD07370485
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human, mouse, rat
• Methode(n): indirect ELISA: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: AAI36381
• UniProt-Hinterlegungsnummer: Q01196
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... RUNX1(861)

Beschreibung

Allgemeine Beschreibung

Runt-related transcription factor 1 (RUNX1) is a transcription factor that plays a crucial role in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Polyomavirus enhancer binding protein 2 (PEBP2) and Moloney murine leukemia virus enhancer core binding factor (CBF). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c.

Anwendung

RUNX1 antibody was raised against a 16 amino acid peptide from near the center of human RUNX1.

Biochem./physiol. Wirkung

RUNX1 (Runt-related transcription factor 1) plays a vital role in tumour suppression and oncogenic activities.[1] In hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy.[3]

Leistungsmerkmale und Vorteile

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Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500417.

Physikalische Form

Supplied in PBS with 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable