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Key Documents

SAB3500318

Sigma-Aldrich

Anti-TMEM16A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-Ano1, Anti-Anoctamin 1, Anti-Calcium activated chloride channel, Anti-DOG1, Anti-TAOS1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

mouse, human

Methode(n)

indirect ELISA: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_060513

UniProt-Hinterlegungsnummer

Q5XXA6

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ANO1(55107)

Allgemeine Beschreibung

Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.

Immunogen

TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.

Biochem./physiol. Wirkung

Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500318.

Physikalische Form

Supplied in PBS with 0.02% sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
Strege PR
American Journal of Physiology: Gastrointestinal and Liver Physiology (2017)
TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
Kulkarni S
Genes Chromosomes Cancer (2017)
GDD1 Is Identical to TMEM16E, a Member of the TMEM16 Family
Masuko K
American Journal of Human Genetics (2004)
Meiyan Sun et al.
Endocrinology, 155(8), 2787-2796 (2014-05-16)
Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was to explore the expression and
Xuan-Yu Wang et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(9), 1298-1310 (2014-07-22)
Interstitial cells of Cajal associated with the submuscular plexus (ICC-SMP) generate omnipresent slow-wave activity in the colon and are associated with prominent motor patterns. Our aim was to investigate colon motor dysfunction in W/W(v) mice in which the ICC are

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