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Merck

SAB2501926

Sigma-Aldrich

Anti-IDO1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(e):

CD107B, HGNC:6059, IDO, INDO, indoleamine-pyrrole 2,3 dioxygenase

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

goat

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

immunohistochemistry: suitable
indirect ELISA: suitable

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... IDO1(3620)

Allgemeine Beschreibung

Indoleamine 2,3 dioxygenase (IDO) 1 is one of the four tryptophan catabolic enzymes in mammals. It codes for a full-length protein, made up of 403 amino acids and has a molecular weight of 45,332 Daltons. It is present in the cytosol. IDO1 is located on human chromosome 8p11.

Immunogen

Peptide with sequence CVLANWKKKDPNK, from the internal region of the protein sequence according to NP_002155.1

Biochem./physiol. Wirkung

Indoleamine 2,3 dioxygenase (IDO) 1 plays an important role in the metabolism of tryptophan and in immune regulation. Removal of IDO1 results in attenuated contact hypersensitivity (CHS) responses.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

IDO1 (indoleamine 2, 3-dioxygenase 1)
Chang Mee Young, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
Indoleamine-2, 3-dioxygenase (IDO) 2 polymorphisms are not associated with multiple sclerosis in Italians
C Agliardi, et al.
Journal of the Neurological Sciences, 377, 31-34 (2017)
Richard Metz et al.
International immunology, 26(7), 357-367 (2014-01-10)
IDO2 is implicated in tryptophan catabolism and immunity but its physiological functions are not well established. Here we report the characterization of mice genetically deficient in IDO2, which develop normally but exhibit defects in IDO-mediated T-cell regulation and inflammatory responses.
Marisa Ryan et al.
American journal of otolaryngology, 35(6), 689-694 (2014-09-13)
1) Assess FoxP3/indoleamine 2,3-dioxygenase immunoreactivity in head and neck melanoma sentinel lymph nodes and 2) correlate FoxP3/indoleamine 2,3-dioxygenase with sentinel lymph node metastasis and clinical recurrence. Retrospective cohort study. Patients with sentinel lymph node biopsy for head and neck melanoma

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