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Key Documents

SAB1405316

Monoclonal Anti-TNS4 antibody produced in mouse

Name: Monoclonal Anti-TNS4 antibody produced in mouse
Brand: SIGMA

clone 1C1, purified immunoglobulin, buffered aqueous solution

Synonym(e):

CTEN, FLJ14950, PP14434

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About This Item

UNSPSC-Code:

12352203

NACRES:

NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

1C1, monoclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~78.91 kDa

Speziesreaktivität

human

Methode(n)

indirect ELISA: suitable
western blot: 1-5 μg/mL

Isotyp

IgG2aκ

NCBI-Hinterlegungsnummer

BC018706

UniProt-Hinterlegungsnummer

Q8IZW8

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... TNS4(84951)

Allgemeine Beschreibung

Mouse monoclonal antibody raised against a full-length recombinant TNS4.

TNS4 (Tensin 4) is a signaling molecule localized in the prostate and placenta. It is a member of the TENSIN gene family. It has a Src homology 2 and phosphotyrosine-binding domains. Its expression has been observed in the early progression of melanoma cells.

Immunogen

TNS4 (AAH18706, 1 a.a. ~ 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM

Anwendung

Monoclonal Anti-TNS4 antibody produced in mouse is suitable for indirect ELISA and western blot.

Biochem./physiol. Wirkung

TNS4 (Tensin 4) is mainly involved in cell migration activity. 1 It exhibits oncogenic property in colonic, breast, lung, and gastric cancers. In studies, its overexpression has been reported in the pancreatic cancer cells. In pancreatic cancer cells, TNS4 promotes colony formation and cell motility. It has been predicted that TNS4 could be a prognostic marker for primary melanoma.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

C-terminal tensin-like protein is a novel prognostic marker for primary melanoma patients.

Cecilia Sjoestroem et al.

PloS one, 8(11), e80492-e80492 (2013-11-19)

C-terminal tensin-like protein (Cten) is a focal adhesion protein originally identified as a tumor suppressor in prostate cancer. It has since been found to be overexpressed and function as an oncogene in numerous other cancers, but the expression status of

Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer.

Su Hao Lo et al.

Cancer research, 62(15), 4217-4221 (2002-08-03)

Tensin is a signaling molecule that binds to actin filaments and localizes to focal adhesions. Recently, we have discovered that tensin represents a new gene family with related members that are expressed in a variety of tissues. In this study

CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis.

Abdulkader Albasri et al.

Breast cancer research and treatment, 126(1), 47-54 (2010-04-15)

C-terminal tensin-like (CTEN) gene is a member of the TENSIN gene family, involved in cell migration and localised at focal adhesion sites. This study was designed to explore the prevalence and clinical significance of CTEN expression in a large and

C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer.

Saleh Al-Ghamdi et al.

Pancreas, 42(1), 135-140 (2012-07-04)

C-terminal tensin-like gene (CTEN, also known as TNS4) localizes to focal adhesions and is reported to function as an oncogene in colonic, breast, lung, and gastric cancers. Its role in pancreatic cancer is unknown and was thus investigated in this

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