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S8251

Sigma-Aldrich

Succinylcholinchlorid Dihydrat

98.0-102.0%, solid

Synonym(e):

Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride

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About This Item

Lineare Formel:
[(CH3)3NCH2CH2OCOCH2]2Cl2 · 2H2O
CAS-Nummer:
6101-15-1
Molekulargewicht:
397.34
Beilstein:
3922827
EG-Nummer:
200-747-4
MDL-Nummer:
MFCD00150564
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24277873
NACRES:
NA.77

Assay

98.0-102.0%

Form

solid

Farbe

white

Löslichkeit

H2O: complete 100 mg/ml, clear to slightly hazy, colorless
H2O: soluble (unstable at pH > 9.)

Ersteller

Novartis

SMILES String

O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

InChI

1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

InChIKey

FFSBEIRFVXGRPR-UHFFFAOYSA-L

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Anwendung

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.4,5

Biochem./physiol. Wirkung

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.
Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.3

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rekonstituierung

Solutions may be stored for several days at 4 °C.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

P-Sätze

P301 + P310

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Increasing our knowledge regarding intrafusal fiber distribution and physiology of paraspinal proprioceptors may provide key insights regarding proprioceptive deficits in trunk control associated with low back pain and lead to more effective clinical intervention. The use of vertebral movement as
J A Jeevendra Martyn et al.
Anesthesiology, 104(1), 158-169 (2006-01-06)
Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area. In certain
Berthold Drexler et al.
Chemico-biological interactions, 206(3), 555-560 (2013-07-11)
Intoxication with organophosphorus compounds is an important clinical problem worldwide. Although the core treatments - atropine, oximes and diazepam - are defined, high case fatalities were reported for intoxication with organophosphorus insecticides. In particular the role of oximes is not
Yumi Sato et al.
Journal of anesthesia, 27(1), 152-156 (2012-12-06)
Recent evidence suggests the possible development of difficult mask ventilation in patients with obstructive sleep apnea. Based on our current understanding of the pathophysiology of pharyngeal airway obstruction in obstructive sleep apnea patients, we conclude that anesthesiologists can decrease respiratory
Brandon H Cline et al.
BMC neuroscience, 13, 110-110 (2012-09-20)
A number of epidemiological studies have established a link between insulin resistance and the prevalence of depression. The occurrence of depression was found to precede the onset of diabetes and was hypothesized to be associated with inherited inter-related insufficiency of
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