S6319

Sertralin -hydrochlorid

≥98% (HPLC)

• Synonym(e): (1S,4S)-4-(3,4-Dichlor-phenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalinamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₇H₁₇NCl₂ · HCl
• CAS-Nummer: 79559-97-0
• Molekulargewicht: 342.69
• MDL-Nummer: MFCD00895772
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278601
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +33 to +43°, c = 2.0 in methanol
• Lagerbedingungen: desiccated
• Farbe: white
• Löslichkeit: DMSO: >20 mg/mL
• SMILES String: ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChIKey: BLFQGGGGFNSJKA-XHXSRVRCSA-N
• Angaben zum Gen: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Beschreibung

Anwendung

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.

Biochem./physiol. Wirkung

Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders. It can also be prescribed to treat depression in Parkinson′s disease.

Ein selektiver Serotonin-Wiederaufnahmehemmer, Antidepressivum

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H373,H410
• P-Sätze: P260 - P264 - P270 - P273 - P301 + P312 - P314
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)