PZ0014

Linezolid

≥98% (HPLC), powder, bacterial mRNA translation inhibitor

• Synonym(e): N-[[(5S)-3-[3-Fluor-4-(4-morpholinyl)-phenyl]-2-oxo-5-oxazolidinyl]-methyl]-acetamid, PNU-100766, U-100766
• Empirische Formel (Hill-System): C₁₆H₂₀FN₃O₄
• CAS-Nummer: 165800-03-3
• Molekulargewicht: 337.35
• MDL-Nummer: MFCD00937825
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329823683
• NACRES: NA.77

Eigenschaften

• product name: Linezolid, ≥98% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >20 mg/mL
• Lagertemp.: room temp
• SMILES String: CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3CCOCC3)c(F)c2
• InChI: 1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
• InChIKey: TYZROVQLWOKYKF-ZDUSSCGKSA-N

Beschreibung

Allgemeine Beschreibung

Linezolid exhibits its activity against several Gram-positive bacteria including penicillin-resistant, methicillin-resistant, and vancomycin- resistant. Linezolid can decrease the rate of translation reaction by inhibiting the formation of initiation complex thereby reducing the length of the newly formed peptidechain. Additionally, it may also play a role in reducing the virulence leading to reduced toxins produced by Gram-positive bacteria.

Anwendung

Linezolid has been used in checkerboard-type drug combination MIC (minimum inhibitory concentrations) assay to determine whether ivacaftor shows positive interaction with linezolid. It has been used for the determination of minimum biofilm inhibitory concentration and for the treatment of Mycobacterium abscessus-infected Drosophila melanogaster w1118 flies.Linezolid has been used as an antibiotic to study its effects on the development of malaria-associated acute respiratory distress syndrome (MAARDS) in rat lungs. It has been used as an antibiotic to study its effects in combination with baicalein on methicillin-resistant Staphylococcus aureus strains. It has been used as an antibiotic to study its effects on planktonic growth and formation of biofilms by Enterococcus faecalis.

Biochem./physiol. Wirkung

Linezolid ist ein Oxazolidinonantimikrobiotikum. Es bindet an eine Stelle der bakteriellen 23S-ribsomalen RNA der 50S-Untereinheit und verhindert die Bildung eines funktionellen 70S-Initiationskomplexes, wodurch es die bakterielle mRNA-Translation hemmt. Linezolid ist auch ein schwacher, reversibler, nicht selektiver Inhibitor von Monoaminoxidase.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H372
• P-Sätze: P260 - P264 - P270 - P314 - P501
• Gefahreneinstufungen: STOT RE 1 Oral
• Zielorgane: Bone
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable