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Merck

PRS4887

Sigma-Aldrich

Anti-IL-17 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-CTLA8, Anti-Interleukin 17A

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human, mouse

Methode(n)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... IL17A(3605)

Allgemeine Beschreibung

IL-17A (interleukin 17A) is a proinflammatory cytokine of Th17 (helper T cells). It is located on chromosome 6p12.

Immunogen

a 19 amino acid peptide from near the center of human IL-17A.

Biochem./physiol. Wirkung

IL-17A (interleukin 17A) plays a major role in the pathogenesis of autoimmune diseases like multiple sclerosis and rheumatoid arthritis. It also plays a pathogenic role in allergic rhinitis (AR). It helps in the formation of several chemokines and cytokines in airway epithelial cells.

Verlinkung

The action of this antibody can be blocked using blocking peptide SBP4887.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Empfehlung

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection
Tsai HC, et al.
Clinical & Developmental Immunology (2013)
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
Ichiyama K, et al.
The Journal of Biological Chemistry, 283(25), 17003-17008 (2008)
Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects
Wang M, et al.
Human immunology, 73(6), 647-653 (2012)
Yugang Wang et al.
International journal of molecular medicine, 33(5), 1131-1139 (2014-02-20)
The aim of the present study was to investigate the clinical efficacy of phased joint intervention [percutaneous transhepatic variceal embolization (PTVE) + phased partial splenic embolization (PSE)] in patients with portal hypertension complicated by esophageal variceal bleeding and hypersplenism and
Jeremy S Schaefer et al.
Gene, 549(1), 134-140 (2014-07-27)
Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation; however, nothing is known about how Rc3h1 expression is regulated. Here, we describe an opposing relationship between Roquin-1 and the IL-17 proinflammatory cytokine by demonstrating that enforced

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