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Merck

PLA0144

Sigma-Aldrich

Rabbit anti-TRF2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(e):

TRBF2, TRF2, TTAGGG repeat-binding factor 2, telomeric DNA-binding protein, telomeric repeat binding protein 2

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Qualität

Powered by Bethyl Laboratories, Inc.

Speziesreaktivität

human

Methode(n)

immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

Hinterlegungsnummer

NP_005643.1

Versandbedingung

wet ice

Lagertemp.

2-8°C

Angaben zum Gen

rabbit ... TRF2(7014)

Allgemeine Beschreibung

The telomeric repeat binding factor 2 (TRF2 ) gene codes for a component of shelterin. The encoded protein is dimer containing four domains : B domain at the N-terminal, the TRF homology domain, the hinge domain and the MYB/SANT (proto-oncogene, transcription factor telobox) domain at C-terminal.

Immunogen

The epitope recognized by PLA0144 maps to a region between residue 375 and 425 of human Telomeric Repeat Binding Factor 2 using the numbering given in entry NP_005643.1 (GeneID 7014).

Biochem./physiol. Wirkung

TRF2 (telomeric repeat binding factor 2) is responsible for telomere stability by the insertion of the 3′ overhang. TRF2 offers protection to DNA from being wrongly recognized by the DNA damage repair systems. Loss of TRF2 function induces DNA repair system resulting in apoptosis by causing cell cycle arrest. Upregulation of the TRF2 gene is observed in cancer and thus concluded to contribute to tumor progression.

Physikalische Form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Sonstige Hinweise

Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2.
Wu M, et al.
Scientific Reports, 6, 36045-36045 (2016)
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.
Benhamou Y, et al.
Oncotarget, 7(28), 44236-44236 (2016)
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Picco V, et al.
Oncotarget, 7(29), 46615-46615 (2016)
Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters.
Chen W, et al.
BioMed Research International, 2017, 9764752-9764752 (2017)

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