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P5372

Sigma-Aldrich

Anti-Potassium Channel Kv7.1 (KCNQ1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(e):

Anti-KVLQT1, Anti-Voltage-gated potassium channel QKT subfamily member 1

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About This Item

MDL-Nummer:
MFCD06798517
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

rat, human

Methode(n)

western blot: 1:200 using rat heart membranes

UniProt-Hinterlegungsnummer

P51787

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... KCNQ1(3784)
mouse ... Kcnq1(16535)
rat ... Kcnq1(84020)

Spezifität

Does not cross react with other QKT proteins.

Immunogen

synthetic peptide corresponding to amino acid residues 661-676 of human KCNQ1. This sequence has 14/16 residues identical in rat and mouse.

Zielbeschreibung

Potassium Channel Kv7.1 (KCNQ1) encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins,

Physikalische Form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Christian A Hübner et al.
Human molecular genetics, 11(20), 2435-2445 (2002-09-28)
Ion channels serve many functions apart from electrical signal transduction: chemical signalling (Ca(2+) as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases
Kazuya Yamagata et al.
Biochemical and biophysical research communications, 407(3), 620-625 (2011-03-24)
KCNQ1, located on 11p15.5, encodes a voltage-gated K(+) channel with six transmembrane regions, and loss-of-function mutations in the KCNQ1 gene cause hereditary long QT syndrome. Recent genetic studies have identified that single nucleotide polymorphisms located in intron 15 of the
J Robbins
Pharmacology & therapeutics, 90(1), 1-19 (2001-07-13)
KCNQ genes encode a growing family of six transmembrane domains, single pore-loop, K(+) channel alpha-subunits that have a wide range of physiological correlates. KCNQ1 (KvLTQ1) is co-assembled with the product of the KCNE1 (minimal K(+)-channel protein) gene in the heart

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